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WHAT TYPE OF GLAUCOMA DO I HAVE?




The type of glaucoma diagnosed by your ophthalmologist determines the treatment options available to you. Here we cut through the confusing medical terminology and provide an explanation for each one.





When I share my diagnosis of glaucoma with a patient, I take as much time as necessary to explain the type of glaucoma that they have and to answer their questions. I do this not just because it is good medicine, but because I have found that the better a patient understands my diagnosis, the more it helps me to explain their treatment plan to them. Answering patients' questions helps to demystify glaucoma and motivates them to participate actively in their treatment.

There are many types of glaucoma and scientists have developed a number of ways to organize them. But for our purposes, the classification scheme used is not particularly relevant. Glaucoma ExamThe main thing to understand is the difference between primary and secondary glaucoma. This distinction relates to underlying cause and is used in naming some types of glaucoma.

To explain the difference, I first have to start with secondary glaucoma. This type of glaucoma has an identifiable disease process, injury, or other source that is causing the glaucoma, such as diabetes, head injury, cataracts, and extended use or overuse of corticosteroids. In other words, the glaucoma is secondary to another health problem.

Primary glaucoma is what is called a diagnosis of exclusion in medicine. This means that I have looked at other reasonable secondary possibilities, like those mentioned previously, and did not find any. The only cause of the glaucoma remaining is a defect within the eye itself.


HOW DOES DETERMINING TYPE OF GLAUCOMA WORK?

As an ophthalmologist, when I see evidence of glaucoma in a patient, I look for secondary causes first. If I am unable to identify any, I then treat the condition as primary glaucoma. Believe it or not, this process is very important.

To illustrate, let's consider a patient with secondary glaucoma due to diabetes that is not well controlled. If the patient does not disclose that they have diabetes to me, or my examination of the patient fails to reveal that diabetes is the underlying problem, then I would treat it as a primary glaucoma case. I would prescribe eye drops to reduce intraocular pressure as a first step in treatment. However, if the patient's diabetes remains poorly controlled, the desired effect of the eye drops will be undermined and the glaucoma will continue to get worse.

For this reason, it is absolutely essential that you disclose all aspects of your medical history along with all medications, prescription or otherwise, that you are taking to your ophthalmologist. Doing this could mean the difference between early diagnosis of the type of glaucoma that you have with effective treatment to manage it, and a delayed diagnosis that allows the glaucoma to worsen before its true underlying cause is identified.

Equally important is following the entire treatment plan prescribed by your ophthalmologist. In the previous example, taking eye drops as prescribed but failing to follow the prescribed treatment plan to control your diabetes, will result in your glaucoma getting worse. The reverse of this also is true. Getting serious about controlling your diabetes but not taking your eye drops as prescribed still can cause additional damage to your optic nerve.


PRIMARY GLAUCOMA

When considering the various types of glaucoma, it is important that you do not lose sight of the fact that they all have a common outcome. This is damage to the optic nerve that if left unchecked can result in progressive, permanent vision loss.

Primary open-angle glaucoma (POAG) is the most common type of glaucoma that I see in my practice and also is the most prevalent form worldwide. It is a chronic condition, meaning that it develops slowly over time, that usually effects persons over 40 years of age. In POAG, intraocular pressure increases because of improper drainage of aqueous humor from the eye. Open angle means that the problem is not in the canals that carry the fluid back into the bloodstream, but rather in the mechanism that filters the aqueous humor before it enters the canals. This is called the trabecular meshwork and it behaves somewhat like the drain strainer in your kitchen sink.

Primary angle-closure glaucoma (PACG) is a less frequent type of glaucoma but this does not make it less serious. It develops when the iris of the eye moves forward, causing the drainage angle for the aqueous humor to exit the eye through the trabecular meshwork to narrow or close. I assess this angle through a test called gonioscopy.

In its acute form, intraocular pressure rises rapidly and is accompanied by pain, along with other symptoms such as red eye, cloudy vision, seeing halos around light sources, and occasionally vomiting. Similar to POAG, the chronic form develops slowly, usually without noticeable symptoms.

Normal tension glaucoma (NTG) is probably the least understood form of the disease. Optic nerve damage occurs even though intraocular pressure is within normal limits. Some scientists believe that this happens because the patients have optic nerve fibers that are highly sensitive to damage. This view is supported by the fact that administration of eye drops to lower intraocular pressure controls progression of the disease in most cases.


VARIANTS OF PRIMARY OPEN-ANGLE GLAUCOMA

  • Pigmentary glaucoma is an hereditary (genetic) type of glaucoma that occurs when pigment granules in the back of the iris (the colored part of the eye) break off into the aqueous humor inside the eye. These tiny pigment granules gradually cause damage to the trabecular meshwork and raise intraocular pressure.
  • Exfoliation glaucoma is another type of glaucoma with known genetic underpinnings. It occurs when a flaky material collects and sloughs off the outer layer of the eye's lens and clogs the drainage system for the aqueous humor.


DEVELOPMENTAL GLAUCOMA

Developmental glaucoma is a rare condition in which the canals that drain aqueous humor from the eye do not form properly. Infants with the disease tend to be sensitive to light and may have cloudy corneas. Cases of developmental glaucoma can have primary and secondary characteristics. For this reason, it treated as a separate category. There are three primary types.

  • Primary congenital glaucoma
  • Infantile glaucoma
  • Juvenile glaucoma
  • Glaucoma associated with hereditary diseases


SECONDARY GLAUCOMA

Secondary glaucoma can occur because of an eye injury, inflammation, tumor, advanced cases of cataract or diabetes, and certain drugs such as steroids. This type of glaucoma may be mild or severe. Treatment options depend on whether it is open angle or closed angle disease.

Neovascular glaucoma is caused by an abnormal formation of new blood vessels on the iris and over the eye’s drainage channels. This never occurs on its own and most often is associated with diabetes. This type of glaucoma is very difficult to treat.

Traumatic glaucoma occurs when there is injury to the eye. The injuries can be caused by blunt trauma that bruise the eye, injuries that penetrate the eye, and even infection. The glaucoma can present itself immediately following the injury or years later.

Inflammatory glaucoma is typically associated with any disease process that causes uveitis, or inflammation of the middle layer (uvea) of the eye. These include systemic disorders, such as systemic lupus erythematosus, infectious agents, such as Herpes simplex and Herpes zoster, and inflammatory syndromes, such as Fuchs Heterochromic Iridocyclitis.

Phacomorphic glaucoma is a form of angle closure disease, usually caused by cataracts or other processes that cause forward displacement of the lens of the eye.

Drug-induced glaucoma is caused most frequently by extended or overuse of corticosteroids and from administration of alpha-chymotrypsin either for cataract surgery or to limit post-surgical swelling following facial surgery.

Intraocular hemorrhage is a condition in which blood is pooling inside the eye. There are two forms that can cause glaucoma: hyphema and hemolytic glaucoma.

Additional secondary causes include a variety of conditions that can raise intraocular pressure.

  • Irido Corneal Endothelial Syndrome (ICE)
  • Post-surgical glaucoma (Aphakic pupillary block, ciliary block)
  • Intraocular tumors
  • Retinal detachment
  • Severe chemical burns of the eye
  • Essential Iris Atrophy
  • Exposure to toxins




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